Description
AZD0156 is a potent, selective and orally active ATM inhibitor with an IC50 of 0.58 nM. AZD0156 inhibits the ATM-mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis.
Product information
CAS Number: 1821428-35-6
Molecular Weight: 461.56
Formula: C26H31N5O3
Chemical Name: 8-{6-[3-(dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(oxan-4-yl)-1H,2H,3H-imidazo[4,5-c]quinolin-2-one
Smiles: CN(C)CCCOC1=CC=C(C=N1)C1=CC=C2N=CC3=C(C2=C1)N(C1CCOCC1)C(=O)N3C
InChiKey: AOTRIQLYUAFVSC-UHFFFAOYSA-N
InChi: InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 4 mg/mL (8.67 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.
Products are for research use only. Not for human use.
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