Catalog No. Size PriceQuantity
M19076-C Contact for quotation $100Unavailable


AZD0156 is a potent, selective and orally active ATM inhibitor with an IC50 of 0.58 nM. AZD0156 inhibits the ATM-mediated signaling, prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis.

Product information

CAS Number: 1821428-35-6

Molecular Weight: 461.56

Formula: C26H31N5O3

Chemical Name: 8-{6-[3-(dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(oxan-4-yl)-1H,2H,3H-imidazo[4,5-c]quinolin-2-one

Smiles: CN(C)CCCOC1=CC=C(C=N1)C1=CC=C2N=CC3=C(C2=C1)N(C1CCOCC1)C(=O)N3C


InChi: InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 4 mg/mL (8.67 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.

Products are for research use only. Not for human use.

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