ZK824859 hydrochloride

Catalog No. Size PriceQuantity
M19118-C Contact sales@xcessbio.com for quotation $100Unavailable


ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.

Product information

CAS Number: 2436760-76-6

Molecular Weight: 464.89

Formula: C23H23ClF2N2O4

Chemical Name: (2R)-2-[(6-{[3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl]oxy}-3,5-difluoropyridin-2-yl)oxy]butanoic acid hydrochloride

Smiles: Cl.CC1C=C(C=C(C=1)OC1N=C(O[C@H](CC)C(O)=O)C(F)=CC=1F)C1C=C(CN)C=CC=1


InChi: InChI=1S/C23H22F2N2O4.ClH/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26;/h4-11,20H,3,12,26H2,1-2H3,(H,28,29);1H/t20-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 125 mg/mL (268.88 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ZK824859 is 5 fold less potent and has lost selectivity in mouse: uPA IC50=410 nM; tPA IC50=910 nM; plasmin IC50=1600 nM compared to human IC50 values of 79 nM, 1580 nM and 1330 nM respectively.

In Vivo:

ZK824859 (50, 25 and 10 mg/kg; b.i.d.; 25 days) is used in a chronic mouse EAE model. ZK 824859 completely prevents the development of disease. However, two lower doses (25 and 10 mg/kg) have no effect on clinical scores.

Products are for research use only. Not for human use.

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