CDK12-IN-3

CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay.

Product information

CAS Number: 2220184-50-7

Molecular Weight: 470.52

Formula: C23H28F2N8O

Chemical Name: 2-[(2S)-1-(6-{[(6,7-difluoro-1H-1,3-benzodiazol-2-yl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl)piperidin-2-yl]ethan-1-ol

Smiles: CC(C)N1C=NC2C1=NC(=NC=2NCC1NC2=C(C=CC(F)=C2F)N=1)N1CCCC[C@H]1CCO

InChiKey: KULPPFCRBINTBS-AWEZNQCLSA-N

InChi: InChI=1S/C23H28F2N8O/c1-13(2)33-12-27-20-21(26-11-17-28-16-7-6-15(24)18(25)19(16)29-17)30-23(31-22(20)33)32-9-4-3-5-14(32)8-10-34/h6-7,12-14,34H,3-5,8-11H2,1-2H3,(H,28,29)(H,26,30,31)/t14-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (531.33 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CDK12-IN-3 is a highly selective CDK12 inhibitor profiled across a panel of 352 kinases at 0.1 µM. CDK12-IN-3 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells.

Products are for research use only. Not for human use.