Description
RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.
Product information
CAS Number: 1417162-36-7
Molecular Weight: 433.28
Formula: C21H18Cl2N2O4
Chemical Name: 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(morpholin-4-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
Smiles: COC1=CC=C(C=C1)C1C(=O)N(C2C=CC(Cl)=C(Cl)C=2)C(=O)C=1N1CCOCC1
InChiKey: JMPJNNOSVCHYOU-UHFFFAOYSA-N
InChi: InChI=1S/C21H18Cl2N2O4/c1-28-15-5-2-13(3-6-15)18-19(24-8-10-29-11-9-24)21(27)25(20(18)26)14-4-7-16(22)17(23)12-14/h2-7,12H,8-11H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 130 mg/mL (300.04 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RI-2 (7a) is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM. RI-2 specifically inhibits homologous recombination repair in human cells. RI-2 (150 μM) induces a significant sensitization of cells.
Products are for research use only. Not for human use.
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