HIV-1 integrase inhibitor 4


Catalog No. Size PriceQuantity
M19388-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM.

Product information

CAS Number: 1638504-66-1

Molecular Weight: 514.50

Formula: C24H20F2N4O5S

Chemical Name: 4-amino-6-[2-(benzenesulfonyl)ethyl]-N-[(2,4-difluorophenyl)methyl]-1-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

Smiles: NC1=C(C(=O)NCC2=CC=C(F)C=C2F)C(=O)N(O)C2=NC=C(CCS(=O)(=O)C3C=CC=CC=3)C=C21

InChiKey: GNATXMRYUGEZME-UHFFFAOYSA-N

InChi: InChI=1S/C24H20F2N4O5S/c25-16-7-6-15(19(26)11-16)13-29-23(31)20-21(27)18-10-14(12-28-22(18)30(33)24(20)32)8-9-36(34,35)17-4-2-1-3-5-17/h1-7,10-12,33H,8-9,13,27H2,(H,29,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

HIV-1 integrase inhibitor 4 (compound 4f) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. HIV-1 integrase inhibitor 4 shows potent activity against recombinant HIV IN in biochemical assays and good efficacy in assays done in cell culture against a broad panel of viral mutants carrying the major RAL and DTG IN resistance mutations.

Products are for research use only. Not for human use.

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