BT-13


Catalog No. Size PriceQuantity
M19412-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat.

Product information

CAS Number: 924537-98-4

Molecular Weight: 517.54

Formula: C23H27F4N3O4S

Chemical Name: N,N-diethyl-3-{4-[4-fluoro-2-(trifluoromethyl)benzoyl]piperazin-1-yl}-4-methoxybenzene-1-sulfonamide

Smiles: COC1=CC=C(C=C1N1CCN(CC1)C(=O)C1=CC=C(F)C=C1C(F)(F)F)S(=O)(=O)N(CC)CC

InChiKey: GTDJOGZANHPKMR-UHFFFAOYSA-N

InChi: InChI=1S/C23H27F4N3O4S/c1-4-30(5-2)35(32,33)17-7-9-21(34-3)20(15-17)28-10-12-29(13-11-28)22(31)18-8-6-16(24)14-19(18)23(25,26)27/h6-9,14-15H,4-5,10-13H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 25 mg/mL (48.31 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET.

In Vivo:

BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy.

Products are for research use only. Not for human use.

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