Description
Rocastine is a selective, nonsedating H1 antagonist, acting as an antihistamine.
Product information
CAS Number: 91833-49-7
Molecular Weight: 265.37
Formula: C13H19N3OS
Chemical Name: 2-[2-(dimethylamino)ethyl]-4-methyl-2H,3H,4H,5H-pyrido[3,2-f][1,4]oxazepine-5-thione
Smiles: CN(C)CCC1CN(C)C(=S)C2=CC=CN=C2O1
InChiKey: DPPDPATYPQFYDL-UHFFFAOYSA-N
InChi: InChI=1S/C13H19N3OS/c1-15(2)8-6-10-9-16(3)13(18)11-5-4-7-14-12(11)17-10/h4-5,7,10H,6,8-9H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Rocastine is effective with a 15 min pretreatment time (PD50 = 0.13 mg/kg) as it is with a 1 hr pretreatment time (PD50 = 0.12 mg/kg). Rocastine protects guinea pigs from collapse induced by aerosolized antigen; rocastine is approximately 36x more potent than diphenhydramine and as potent as oxatomide and terfenadine. Rocastine does not alter the EEG of cats at doses in vast excess (150x) of its antihistaminic dose nor does it potentiate yohimbine toxicity in mice.
Products are for research use only. Not for human use.
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