Description
PF-998425 is a potent, selective nonsteroidal androgen receptor (AR) antagonist with an IC50 of 37 nM and 43 nM in AR binding and cellular assays, respectively. PF-998425 has low activity on common receptors and enzymes, such as progesterone receptor. PF-998425 can be used for sebum control and androgenetic alopecia research.
Product information
CAS Number: 1076225-27-8
Molecular Weight: 269.26
Formula: C14H14F3NO
Chemical Name: 4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)benzonitrile
Smiles: N#CC1C=CC(=CC=1C(F)(F)F)[C@H]1CCCC[C@H]1O
InChiKey: MENRRRXHFQYXDW-DGCLKSJQSA-N
InChi: InChI=1S/C14H14F3NO/c15-14(16,17)12-7-9(5-6-10(12)8-18)11-3-1-2-4-13(11)19/h5-7,11,13,19H,1-4H2/t11-,13-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
PF-998425 (Compound (-)-6a) is rapidly metabolized in rat liver microsomes (t1/2=4 min, CLint=350 (µL/min)/mg protein). In vivo clearance data in dogs are consistent with the high clearance predicted in vitro in rat. Following intravenous administration of PF-998425, mean systemic plasma clearance is 40 (mL/min)/kg. The mean apparent of volume of distribution at steady state is 6.5 L/kg, and the mean terminal phase half-life is 2.6 h.
Products are for research use only. Not for human use.
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