AZ191


Catalog No. Size PriceQuantity
M19517-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AZ191 is a potent inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM.

Product information

CAS Number: 1594092-37-1

Molecular Weight: 429.52

Formula: C24H27N7O

Chemical Name: N-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-{1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl}pyrimidin-2-amine

Smiles: CN1CCN(CC1)C1=CC(OC)=C(C=C1)NC1N=C(C=CN=1)C1=CN(C)C2C=NC=CC=21

InChiKey: ZYVXTMKTGDARKR-UHFFFAOYSA-N

InChi: InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 30 mg/mL (69.85 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

AZ191 (0.01-60μM; 5 days) inhibits SW872 and SW982 cell lines in dose-dependent manner with IC50s of 3.183 μM and 1.279 μM, respectively. AZ191 (1-5 μM; 48 hours) down-regulates three anti-apoptotic proteins (Bcl-2, p21, and survivin) at higher concentrations.

Products are for research use only. Not for human use.

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