Description
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation.
Product information
CAS Number: 36011-19-5
Molecular Weight: 495.56
Formula: C28H33NO7
Chemical Name: (7R,9S,13S,14S,16R,17S,18S,19S)-19-benzyl-7-hydroxy-7,9,16,17-tetramethyl-2,4,15-trioxa-20-azatetracyclo[11.8.0.0¹,¹⁸.0¹⁴,¹⁶]henicosa-5,11-diene-3,8,21-trione
Smiles: C[C@]12O[C@H]1[C@@H]1C=CC[C@H](C)C(=O)[C@](C)(O)C=COC(=O)OC31[C@H]([C@H](CC1C=CC=CC=1)NC3=O)[C@@H]2C |t:6,16|
InChiKey: LAJXCUNOQSHRJO-FORGOZIJSA-N
InChi: InChI=1S/C28H33NO7/c1-16-9-8-12-19-23-27(4,35-23)17(2)21-20(15-18-10-6-5-7-11-18)29-24(31)28(19,21)36-25(32)34-14-13-26(3,33)22(16)30/h5-8,10-14,16-17,19-21,23,33H,9,15H2,1-4H3,(H,29,31)/b12-8-,14-13-/t16-,17-,19-,20-,21-,23-,26+,27+,28?/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner. Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62.
Products are for research use only. Not for human use.
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