Hypophyllanthin


Catalog No. Size PriceQuantity
M19580-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity.

Product information

CAS Number: 33676-00-5

Molecular Weight: 430.49

Formula: C24H30O7

Chemical Name: (7S,8S,9R)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-2H,6H,7H,8H,9H-naphtho[1,2-d][1,3]dioxole

Smiles: COC1C=C(C=CC=1OC)[C@H]1[C@H](COC)[C@H](CC2=CC(OC)=C3OCOC3=C21)COC

InChiKey: LBJCUHLNHSKZBW-LZJOCLMNSA-N

InChi: InChI=1S/C24H30O7/c1-25-11-16-8-15-10-20(29-5)23-24(31-13-30-23)22(15)21(17(16)12-26-2)14-6-7-18(27-3)19(9-14)28-4/h6-7,9-10,16-17,21H,8,11-13H2,1-5H3/t16-,17-,21+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (232.29 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Hypophyllanthin down-regulates COX-2, TNF-α, and IL-1β gene expressions in U937 macrophages by interfering with the activation of NF-κB, MAPKs, and Akt.

Products are for research use only. Not for human use.

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