CK-666


Catalog No. Size PriceQuantity
M19662-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.

Product information

CAS Number: 442633-00-3

Molecular Weight: 296.34

Formula: C18H17FN2O

Chemical Name: 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide

Smiles: CC1NC2=CC=CC=C2C=1CCNC(=O)C1=CC=CC=C1F

InChiKey: UXRKUKRXVWJFER-UHFFFAOYSA-N

InChi: InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (421.81 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CK-666 (100 μM) significantly reduces the number of filopodia on the cell surface of treated trabecular meshwork (TM) cells as well as reduces the length of those filopodia that are present.

Products are for research use only. Not for human use.

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