Apimostinel


Catalog No. Size PriceQuantity
M19783-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist.

Product information

CAS Number: 1421866-48-9

Molecular Weight: 503.59

Formula: C25H37N5O6

Chemical Name: (2S,3R)-2-{[(2R)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-2-benzylpyrrolidin-2-yl]formamido}-3-hydroxybutanamide

Smiles: C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@]1(CC1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

InChiKey: DVBUEXCIEIAXPM-PJUQSVSOSA-N

InChi: InChI=1S/C25H37N5O6/c1-15(31)19(26)23(35)29-12-6-10-18(29)22(34)30-13-7-11-25(30,14-17-8-4-3-5-9-17)24(36)28-20(16(2)32)21(27)33/h3-5,8-9,15-16,18-20,31-32H,6-7,10-14,26H2,1-2H3,(H2,27,33)(H,28,36)/t15-,16-,18+,19+,20+,25-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 155 mg/mL (307.79 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Apimostinel (NRX-1074) modulates the NMDA receptor in a similar fashion to GLYX-13, but has a synthetic modification to one of the amino acids, conferring increased potency and oral bioavailability.

In Vivo:

In preclinical models the two compounds both appear to be highly efficacious across a number of CNS disorders.

Products are for research use only. Not for human use.

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