Description
A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases.
Product information
CAS Number: 251992-66-2
Molecular Weight: 300.40
Formula: C15H12N2OS2
Chemical Name: 4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxamide
Smiles: CC1C=CC(=CC=1)SC1=CN=CC2SC(=CC=21)C(N)=O
InChiKey: QQGWEXFLMJGCAL-UHFFFAOYSA-N
InChi: InChI=1S/C15H12N2OS2/c1-9-2-4-10(5-3-9)19-13-7-17-8-14-11(13)6-12(20-14)15(16)18/h2-8H,1H3,(H2,16,18)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (416.11 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
A-205804 exhibits Cellular Toxicities for HUVEC with an IC50 of 152 μM. A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system.
In Vivo:
A-205804 (5 mg/kg; p.o.) shows a half-life of 1 hour for rat. A-205804 (10 mg/kg; p.o.; 3 times per week; for 2 weeks) attenuates the E-selectin expression on the endothelial vascular niche cells in mice.
Products are for research use only. Not for human use.
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