DDP-38003 dihydrochloride


Catalog No. Size PriceQuantity
M19949-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.

Product information

CAS Number: 1831167-98-6

Molecular Weight: 423.38

Formula: C21H28Cl2N4O

Chemical Name: N-{4-[(1S,2R)-2-aminocyclopropyl]phenyl}-4-(4-methylpiperazin-1-yl)benzamide dihydrochloride

Smiles: Cl.Cl.CN1CCN(CC1)C1C=CC(=CC=1)C(=O)NC1C=CC(=CC=1)[C@@H]1C[C@H]1N

InChiKey: HFSFENIQYFFMGC-HUQPAIQZSA-N

InChi: InChI=1S/C21H26N4O.2ClH/c1-24-10-12-25(13-11-24)18-8-4-16(5-9-18)21(26)23-17-6-2-15(3-7-17)19-14-20(19)22;;/h2-9,19-20H,10-14,22H2,1H3,(H,23,26);2*1H/t19-,20+;;/m0../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 29 mg/mL (68.50 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue.

In Vivo:

DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent.

Products are for research use only. Not for human use.

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