5-HT4 antagonist 1


Catalog No. Size PriceQuantity
M20091-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.

Product information

CAS Number: 261766-73-8

Molecular Weight: 480.62

Formula: C23H36N4O5S

Chemical Name: N-[(1-{3-[(4-methylpiperazin-1-yl)sulfonyl]propyl}piperidin-4-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxamide

Smiles: CN1CCN(CC1)S(=O)(=O)CCCN1CCC(CNC(=O)C2C=CC=C3OCCOC3=2)CC1

InChiKey: AUXZCLHKLUWDDZ-UHFFFAOYSA-N

InChi: InChI=1S/C23H36N4O5S/c1-25-11-13-27(14-12-25)33(29,30)17-3-8-26-9-6-19(7-10-26)18-24-23(28)20-4-2-5-21-22(20)32-16-15-31-21/h2,4-5,19H,3,6-18H2,1H3,(H,24,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6.

In Vivo:

5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h.

Products are for research use only. Not for human use.

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