Description
CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.
Product information
CAS Number: 916047-16-0
Molecular Weight: 451.23
Formula: C20H13Cl2FN2O5
Chemical Name: 2-{5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-1-yl}acetic acid
Smiles: OC(=O)CN1C2=CC=C(Cl)C=C2C2(CC(=O)N(CC3C=C(Cl)C=CC=3F)C2=O)C1=O
InChiKey: IXKFWNVFUXXEFY-UHFFFAOYSA-N
InChi: InChI=1S/C20H13Cl2FN2O5/c21-11-1-3-14(23)10(5-11)8-25-16(26)7-20(19(25)30)13-6-12(22)2-4-15(13)24(18(20)29)9-17(27)28/h1-6H,7-9H2,(H,27,28)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CAY10595 (compound 71) is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.
In Vivo:
Administration of the DP2 antagonist CAY10595 slightly delays the development of CIA. Treatment with CAY10595 reduces IgG2a anti-CII levels without modification of IgG anti-CII levels.
Products are for research use only. Not for human use.
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