Description
Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain.
Product information
CAS Number: 1050670-85-3
Molecular Weight: 474.29
Formula: C17H23IN4O4
Chemical Name: 2-({4-amino-5-[5-iodo-4-methoxy-2-(propan-2-yl)phenoxy]pyrimidin-2-yl}amino)propane-1,3-diol
Smiles: CC(C)C1=CC(OC)=C(I)C=C1OC1=CN=C(NC(CO)CO)N=C1N
InChiKey: PAYROHWFGZADBR-UHFFFAOYSA-N
InChi: InChI=1S/C17H23IN4O4/c1-9(2)11-4-14(25-3)12(18)5-13(11)26-15-6-20-17(22-16(15)19)21-10(7-23)8-24/h4-6,9-10,23-24H,7-8H2,1-3H3,(H3,19,20,21,22)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Ro-51 has highly selective for P2X 3 and P2X 2/3 exhibiting no antagonistic activity at other P2X receptor family members tested (P2X 1 , P2X 2 , P2X 4 , P2X 5 , and P2X 7 ) at concentrations up to 10 μM. RO51 also shows a significant drop in potency on human P2X3 receptors (IC50 = 110.5 and 0.04 nM, respectively for human and rat P2X3).
In Vivo:
Ro-51 suffers rapid clearance, short half-lives, and high protein binding in rat.
Products are for research use only. Not for human use.
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