Description
CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.
Product information
CAS Number: 1873376-49-8
Molecular Weight: 476.35
Formula: C19H20Cl2FN3O4S
Chemical Name: 3-{4-chloro-2-hydroxy-3-[(1-methylpiperidin-4-yl)sulfonyl]phenyl}-1-(2-chloro-3-fluorophenyl)urea
Smiles: CN1CCC(CC1)S(=O)(=O)C1=C(O)C(=CC=C1Cl)NC(=O)NC1=CC=CC(F)=C1Cl
InChiKey: BJYOBCUGMDKPBM-UHFFFAOYSA-N
InChi: InChI=1S/C19H20Cl2FN3O4S/c1-25-9-7-11(8-10-25)30(28,29)18-12(20)5-6-15(17(18)26)24-19(27)23-14-4-2-3-13(22)16(14)21/h2-6,11,26H,7-10H2,1H3,(H2,23,24,27)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 5.4 mg/mL (11.34 mM; Need ultrasonic and warming).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45).
In Vivo:
CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis.
Products are for research use only. Not for human use.
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