SC57666


Catalog No. Size PriceQuantity
M20261-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM.

Product information

CAS Number: 158959-32-1

Molecular Weight: 316.39

Formula: C18H17FO2S

Chemical Name: 1-[2-(4-fluorophenyl)cyclopent-1-en-1-yl]-4-methanesulfonylbenzene

Smiles: CS(=O)(=O)C1C=CC(=CC=1)C1CCCC=1C1C=CC(F)=CC=1

InChiKey: GJGZQTGPOKPFES-UHFFFAOYSA-N

InChi: InChI=1S/C18H17FO2S/c1-22(20,21)16-11-7-14(8-12-16)18-4-2-3-17(18)13-5-9-15(19)10-6-13/h5-12H,2-4H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 100 mg/mL (316.07 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SC57666 inhibits COX2 with an IC50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC50=6000±1900 nM).

In Vivo:

SC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk.

Products are for research use only. Not for human use.

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