Description
MK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC50 of 10.5 nM.
Product information
CAS Number: 1201323-97-8
Molecular Weight: 268.25
Formula: C14H9FN4O
Chemical Name: 5-{5-fluoro-[1,3]oxazolo[5,4-b]pyridin-2-yl}-1-methyl-1H-pyrrolo[2,3-b]pyridine
Smiles: CN1C=CC2=CC(=CN=C12)C1=NC2=CC=C(F)N=C2O1
InChiKey: WYQHKOHCTMNFAU-UHFFFAOYSA-N
InChi: InChI=1S/C14H9FN4O/c1-19-5-4-8-6-9(7-16-12(8)19)13-17-10-2-3-11(15)18-14(10)20-13/h2-7H,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
MK-3328 exhibits amyloid binding potency balanced with low levels of nonspecific binding.
In Vivo:
In vivo, [18F]MK-3328 demonstrates favorable kinetics, exhibiting high brain uptake and good washout in normal rhesus monkey positron emission tomography (PET) imaging studies.
Products are for research use only. Not for human use.
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