Indatraline hydrochloride


Catalog No. Size PriceQuantity
M20317-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine) with efficacy similar to cocaine. Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis.

Product information

CAS Number: 96850-13-4

Molecular Weight: 328.66

Formula: C16H16Cl3N

Chemical Name: (1R,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine hydrochloride

Smiles: Cl.CN[C@@H]1C[C@H](C2=CC=CC=C21)C1C=C(Cl)C(Cl)=CC=1

InChiKey: QICQDZXGZOVTEF-MELYUZJYSA-N

InChi: InChI=1S/C16H15Cl2N.ClH/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10;/h2-8,13,16,19H,9H2,1H3;1H/t13-,16+;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Indatraline (0~5 μM; 24 hours; EGFP-LC3 stable cells) hydrochloride makes the concentration-dependent conversion of LC3. Indatraline (1~10 μM; 24 hours; HeLa cells) hydrochloride makes EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm. Indatraline (1~20 μM; smooth muscle cells) hydrochloride inhibits smooth muscle cells proliferation with an IC50 of 15 μM. Indatraline hydrochloride induces autophagy in cells. Indatraline hydrochloride affects AMPK/mTOR/S6K signaling axis.

In Vivo:

Indatraline (2 μM) hydrochloride inhibits neointimal accumulation of smooth muscle cells.

Products are for research use only. Not for human use.

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