6-Chloromelatonin


Catalog No. Size PriceQuantity
M20323-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [3H]-melatonin and 2-[125I]-iodomelatonin binding to MT1 receptors (pKi=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [3H]-melatonin binding to MT2 receptors (pKi=9.77).

Product information

CAS Number: 63762-74-3

Molecular Weight: 266.72

Formula: C13H15ClN2O2

Chemical Name: N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamide

Smiles: CC(=O)NCCC1=CNC2=CC(Cl)=C(C=C12)OC

InChiKey: LUINDDOUWHRIPW-UHFFFAOYSA-N

InChi: InChI=1S/C13H15ClN2O2/c1-8(17)15-4-3-9-7-16-12-6-11(14)13(18-2)5-10(9)12/h5-7,16H,3-4H2,1-2H3,(H,15,17)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

6-Chloromelatonin competes for [3H]-melatonin binding sites in human platelet (Ki=11.4 nM). 6-chloromelatonin (10 pM, 1 nM, 100 nM, 10 μM; 72 hours) inhibits, in a dose-dependent manner, forskolin-stimulated hCG-beta secretion in JEG-3 and BeWo cells but had no effect on basal human chorionic gonadotrophin (hCG-beta) levels.

In Vivo:

Rats injected with the melatonin agonist, 6-chloromelatonin (0.5 mg/kg) on the day after the phase shift has markedly higher excretion rates of 6-sulphatoxymelatonin compared to those of the controls.

Products are for research use only. Not for human use.

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