BX517


Catalog No. Size PriceQuantity
M20430-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.

Product information

CAS Number: 850717-64-5

Molecular Weight: 282.30

Formula: C15H14N4O2

Chemical Name: N-[(3Z)-2-hydroxy-3-[1-(1H-pyrrol-2-yl)ethylidene]-3H-indol-5-yl]carbamimidic acid

Smiles: C/C(=C1\C2C=C(C=CC=2N=C\1O)NC(=N)O)/C1=CC=CN1

InChiKey: DFURSNCTQGJRRX-JYRVWZFOSA-N

InChi: InChI=1S/C15H14N4O2/c1-8(11-3-2-6-17-11)13-10-7-9(18-15(16)21)4-5-12(10)19-14(13)20/h2-7,17H,1H3,(H,19,20)(H3,16,18,21)/b13-8-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 27 mg/mL (95.64 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BX-517 blocks activation of Akt in tumor cells, is potent with IC50 of 0.1-1.0 μM. BX-517 blocks AKT2 activation in cells with submicromolar potency. BX-517 is 100-fold selective or better against a panel of seven additional Ser/Thr and Tyr kinases.

Products are for research use only. Not for human use.

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