Description
Proxyphylline is a methylxanthine derivative used as a cardiac stimulant, vasodilator and bronchodilator.
Product information
CAS Number: 603-00-9
Molecular Weight: 238.24
Formula: C10H14N4O3
Chemical Name: 7-(2-hydroxypropyl)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Smiles: CC(O)CN1C=NC2=C1C(=O)N(C)C(=O)N2C
InChiKey: KYHQZNGJUGFTGR-UHFFFAOYSA-N
InChi: InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 100 mg/mL (419.74 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Proxyphylline has shown vasodilatory and cardiac stimulatory effects. Proxyphylline produces an increase in the coronary flow associated with a definite positive inotropic effect. Proxyphylline inhibits tracheal PDE-activity and half-maximum relaxation of tracheal smooth muscle is obtained with 100 μg/mL proxyphylline
In Vivo:
Proxyphylline exhibits bronchodilatory effect. Proxyphylline inhibits cAMP and cGMP hydrolysis in human lung tissue. The apparent inhibition constant of proxyphylline is 0.06-0.7 mM at low cAMP concentrations and it is 1.0 mM at high cAMP concentrations.
Products are for research use only. Not for human use.
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