Description
OT antagonist 1 (Compound 4) is a potent, selective Oxytocin antagonist with a Ki of 50 nM.
Product information
CAS Number: 479080-38-1
Molecular Weight: 390.44
Formula: C22H22N4O3
Chemical Name: (3E,5S)-N-methoxy-5-(3-methyl-1,2,4-oxadiazol-5-yl)-1-{2'-methyl-[1,1'-biphenyl]-4-carbonyl}pyrrolidin-3-imine
Smiles: CO/N=C1\C[C@@H](C2=NC(C)=NO2)N(C\1)C(=O)C1C=CC(=CC=1)C1=CC=CC=C1C
InChiKey: PFGOHCJFGDEHAX-HBTCSRNFSA-N
InChi: InChI=1S/C22H22N4O3/c1-14-6-4-5-7-19(14)16-8-10-17(11-9-16)22(27)26-13-18(25-28-3)12-20(26)21-23-15(2)24-29-21/h4-11,20H,12-13H2,1-3H3/b25-18+/t20-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Oxytocin (OT) is a nonapeptide hormone that acts on the OT receptor, a seven-transmembrane (7TM) (Gq-coupled) receptor. The OT receptor has no subtypes but is related to the vasopressin receptors V1A, V1B and V2. OT antagonists have therapeutic potential in a number of areas including pre-term labour: Benign Prostatic Hyperplasia and sexual dysfunction. As a result there is significant interest in the identification of potent, selective, orally bioavailable OT antagonists.
Products are for research use only. Not for human use.
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