Description
Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth.
Product information
CAS Number: 1874-54-0
Molecular Weight: 297.27
Formula: C11H15N5O5
Chemical Name: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-2,5-bis(hydroxymethyl)oxolane-3,4-diol
Smiles: NC1=NC=NC2=C1N=CN2[C@]1(CO)O[C@H](CO)[C@@H](O)[C@H]1O
InChiKey: BNZYRKVSCLSXSJ-IOSLPCCCSA-N
InChi: InChI=1S/C11H15N5O5/c12-9-6-10(14-3-13-9)16(4-15-6)11(2-18)8(20)7(19)5(1-17)21-11/h3-5,7-8,17-20H,1-2H2,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 50 mg/mL (168.20 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Psicofuranine specifically inhibits bacterial GMP synthase as demonstrated by isolation of Psicofuranine-resistant Escherichia coli mutants with mutations in the gene encoding GMP synthase and inhibition of bacterial growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth with an IC50 of 0.3 mM. The Psicofuranine inhibitory concentration is similar to that of E. coli.
Products are for research use only. Not for human use.
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