Ro 41-1049 hydrochloride


Catalog No. Size PriceQuantity
M20716-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (MAO-A). An homogeneous population of high affinity binding sites for [3H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta (Kd values of 16.5 and 64.4 nM, respectively).

Product information

CAS Number: 127917-66-2

Molecular Weight: 301.77

Formula: C12H13ClFN3OS

Chemical Name: N-(2-aminoethyl)-5-(3-fluorophenyl)-1,3-thiazole-4-carboxamide hydrochloride

Smiles: Cl.NCCNC(=O)C1N=CSC=1C1C=C(F)C=CC=1

InChiKey: RRNSPXUFTKJIEZ-UHFFFAOYSA-N

InChi: InChI=1S/C12H12FN3OS.ClH/c13-9-3-1-2-8(6-9)11-10(16-7-18-11)12(17)15-5-4-14;/h1-3,6-7H,4-5,14H2,(H,15,17);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 32 mg/mL (106.04 mM). H2O : 25 mg/mL (82.84 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion. Pretreatment with Ro 41-1049 (20 mg/kg) significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing formation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA).

Products are for research use only. Not for human use.

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