PSB-12062


Catalog No. Size PriceQuantity
M20757-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

PSB-12062 is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4.

Product information

CAS Number: 55476-47-6

Molecular Weight: 337.39

Formula: C19H15NO3S

Chemical Name: 10-(4-methylbenzenesulfonyl)-10H-phenoxazine

Smiles: CC1C=CC(=CC=1)S(=O)(=O)N1C2=CC=CC=C2OC2C=CC=CC1=2

InChiKey: DHZNMEIBMACSFH-UHFFFAOYSA-N

InChi: InChI=1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 25 mg/mL (74.10 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM).

Products are for research use only. Not for human use.

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