Pumaprazole


Catalog No. Size PriceQuantity
M20773-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Pumaprazole is a reversible proton pump antagonist.

Product information

CAS Number: 158364-59-1

Molecular Weight: 338.40

Formula: C19H22N4O2

Chemical Name: methyl N-{2-[({2,3-dimethylimidazo[1,2-a]pyridin-8-yl}amino)methyl]-3-methylphenyl}carbamate

Smiles: CC1N=C2C(=CC=CN2C=1C)NCC1C(=CC=CC=1C)NC(=O)OC

InChiKey: NZQTVUWEPPDOKK-UHFFFAOYSA-N

InChi: InChI=1S/C19H22N4O2/c1-12-7-5-8-16(22-19(24)25-4)15(12)11-20-17-9-6-10-23-14(3)13(2)21-18(17)23/h5-10,20H,11H2,1-4H3,(H,22,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Pumaprazole is a reversible proton pump antagonist. Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compare to ranitidine. Pumaprazole displays identical ID50 values on day 1 (11 μmol/kg, 95% confidence limits of 5 and 23) and on day 7 (10 μmol/kg, 95% confidence limits of 4 and 23) of a repeated dose study in this model. The lower dose of Pumaprazole (27 μmol/kg) rapidly elevates luminal pH up to almost neutrality, the higher dose (54 μmol/kg) further prolongs this pH-elevating effect.

Products are for research use only. Not for human use.

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