CM-579


Catalog No. Size PriceQuantity
M20782-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.

Product information

CAS Number: 1846570-40-8

Molecular Weight: 492.65

Formula: C29H40N4O3

Chemical Name: 6-methoxy-2-(5-methylfuran-2-yl)-N-[(1-methylpiperidin-4-yl)methyl]-7-[3-(pyrrolidin-1-yl)propoxy]quinolin-4-amine

Smiles: CN1CCC(CNC2=CC(=NC3=CC(OCCCN4CCCC4)=C(C=C32)OC)C2=CC=C(C)O2)CC1

InChiKey: VMMRDFLDWHFNOX-UHFFFAOYSA-N

InChi: InChI=1S/C29H40N4O3/c1-21-7-8-27(36-21)26-18-24(30-20-22-9-14-32(2)15-10-22)23-17-28(34-3)29(19-25(23)31-26)35-16-6-13-33-11-4-5-12-33/h7-8,17-19,22H,4-6,9-16,20H2,1-3H3,(H,30,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively.

Products are for research use only. Not for human use.

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