Description
RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5.
Product information
CAS Number: 1306761-53-4
Molecular Weight: 432.47
Formula: C24H24N4O4
Chemical Name: 3-[(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]-1, 2, 4-oxadiazol-3-yl}-2, 3-dihydro-1H-inden-1-yl)amino]propanoic acid
Smiles: CC(C)OC1=CC=C(C=C1C#N)C1=NC(=NO1)C1=CC=CC2C(CCC1=2)NCCC(O)=O
InChiKey: WNDDDFYFTSGSEC-UHFFFAOYSA-N
InChi: InChI=1S/C24H24N4O4/c1-14(2)31-21-9-6-15(12-16(21)13-25)24-27-23(28-32-24)19-5-3-4-18-17(19)7-8-20(18)26-11-10-22(29)30/h3-6,9,12,14,20,26H,7-8,10-11H2,1-2H3,(H,29,30)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RP-001 elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 induces acute lymphopenia with rapid recovery to untreated levels.
In Vivo:
RP-001 causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
