RP-001 hydrochloride


Catalog No. Size PriceQuantity
M20866-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5.

Product information

CAS Number: 1781880-34-9

Molecular Weight: 468.93

Formula: C24H25ClN4O4

Chemical Name: 3-[(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]-1,2,4-oxadiazol-3-yl}-2,3-dihydro-1H-inden-1-yl)amino]propanoic acid hydrochloride

Smiles: Cl.CC(C)OC1=CC=C(C=C1C#N)C1=NC(=NO1)C1=CC=CC2C(CCC1=2)NCCC(O)=O

InChiKey: ZHPGSGYEFGEZAL-UHFFFAOYSA-N

InChi: InChI=1S/C24H24N4O4.ClH/c1-14(2)31-21-9-6-15(12-16(21)13-25)24-27-23(28-32-24)19-5-3-4-18-17(19)7-8-20(18)26-11-10-22(29)30;/h3-6,9,12,14,20,26H,7-8,10-11H2,1-2H3,(H,29,30);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

RP-001 hydrochloride elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels.

In Vivo:

RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg.

Products are for research use only. Not for human use.

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