Description
JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth.
Product information
CAS Number: 442644-28-2
Molecular Weight: 394.38
Formula: C21H18N2O6
Chemical Name: trispiro[indole-3,2':5',5''-bis([1,3]dioxane)-2'',3'''-indole]-2,2'''-diol
Smiles: OC1=NC2=CC=CC=C2C21OCC1(CO2)COC2(OC1)C1=CC=CC=C1N=C2O
InChiKey: BTXRSHKJNDFHGA-UHFFFAOYSA-N
InChi: InChI=1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin. JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines. JW67 shows a concentrationdependent reduction in proliferation with a GI50 value of 7.8 μM.
Products are for research use only. Not for human use.
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