Description
HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS.
Product information
CAS Number: 162641-16-9
Molecular Weight: 377.48
Formula: C22H27N5O
Chemical Name: 4-(diphenylmethoxy)-1-[3-(2H-1,2,3,4-tetrazol-5-yl)propyl]piperidine
Smiles: C(CCN1CCC(CC1)OC(C1=CC=CC=C1)C1=CC=CC=C1)C1N=NNN=1
InChiKey: TZQGXAHOROZEKN-UHFFFAOYSA-N
InChi: InChI=1S/C22H27N5O/c1-3-8-18(9-4-1)22(19-10-5-2-6-11-19)28-20-13-16-27(17-14-20)15-7-12-21-23-25-26-24-21/h1-6,8-11,20,22H,7,12-17H2,(H,23,24,25,26)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH.
Products are for research use only. Not for human use.
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