SIS3 free base


Catalog No. Size PriceQuantity
M21134-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2.

Product information

CAS Number: 1009104-85-1

Molecular Weight: 453.53

Formula: C28H27N3O3

Chemical Name: (2E)-1-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-3-{1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl}prop-2-en-1-one

Smiles: CN1C(=C(/C=C/C(=O)N2CC3C=C(OC)C(=CC=3CC2)OC)C2C=CC=NC1=2)C1C=CC=CC=1

InChiKey: IJYPHMXWKKKHGT-VAWYXSNFSA-N

InChi: InChI=1S/C28H27N3O3/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31/h4-12,14,16-17H,13,15,18H2,1-3H3/b12-11+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.

Products are for research use only. Not for human use.

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