Description
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2.
Product information
CAS Number: 1009104-85-1
Molecular Weight: 453.53
Formula: C28H27N3O3
Chemical Name: (2E)-1-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-3-{1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl}prop-2-en-1-one
Smiles: CN1C(=C(/C=C/C(=O)N2CC3C=C(OC)C(=CC=3CC2)OC)C2C=CC=NC1=2)C1C=CC=CC=1
InChiKey: IJYPHMXWKKKHGT-VAWYXSNFSA-N
InChi: InChI=1S/C28H27N3O3/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31/h4-12,14,16-17H,13,15,18H2,1-3H3/b12-11+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.
Products are for research use only. Not for human use.
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