Description
PNU-177864 hydrochloride is a potent, selective and orally active dopamine D3 receptor antagonist. PNU-177864 hydrochloride is structurally consistent with a cationic amphiphilic drug (CAD) and induces phospholipidosis in vivo. PNU-177864 hydrochloride antischizophrenic activity.
Product information
CAS Number: 1783978-03-9
Molecular Weight: 438.89
Formula: C18H22ClF3N2O3S
Chemical Name: N-{4-[2-(propylamino)ethyl]phenyl}-4-(trifluoromethoxy)benzene-1-sulfonamide hydrochloride
Smiles: Cl.CCCNCCC1=CC=C(C=C1)NS(=O)(=O)C1C=CC(=CC=1)OC(F)(F)F
InChiKey: UOMDLHQTLPWCCE-UHFFFAOYSA-N
InChi: InChI=1S/C18H21F3N2O3S.ClH/c1-2-12-22-13-11-14-3-5-15(6-4-14)23-27(24,25)17-9-7-16(8-10-17)26-18(19,20)21;/h3-10,22-23H,2,11-13H2,1H3;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
PNU-177864 (12.5-200 mg/kg; oral gavage; daily; for 2-4 weeks; Sprague-Dawley rats) treatment induces phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles.
Products are for research use only. Not for human use.
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