Description
CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer.
Product information
CAS Number: 2437547-04-9
Molecular Weight: 504.52
Formula: C24H23F3N4O3S
Chemical Name: 4-(4-{[(1r,4r)-4-{[5-(trifluoromethyl)pyridin-2-yl]amino}cyclohexyl]sulfonyl}phenyl)pyridine-2-carboxamide
Smiles: NC(=O)C1=CC(=CC=N1)C1C=CC(=CC=1)S(=O)(=O)[C@@H]1CC[C@H](CC1)NC1C=CC(=CN=1)C(F)(F)F
InChiKey: CNOZLNNAVQPFBD-KESTWPANSA-N
InChi: InChI=1S/C24H23F3N4O3S/c25-24(26,27)17-3-10-22(30-14-17)31-18-4-8-20(9-5-18)35(33,34)19-6-1-15(2-7-19)16-11-12-29-21(13-16)23(28)32/h1-3,6-7,10-14,18,20H,4-5,8-9H2,(H2,28,32)(H,30,31)/t18-,20-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 125 mg/mL (247.76 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration.
Products are for research use only. Not for human use.
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