Rolofylline


Catalog No. Size PriceQuantity
M21250-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment.Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450).Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.

Product information

CAS Number: 136199-02-5

Molecular Weight: 356.46

Formula: C20H28N4O2

Chemical Name: 1,3-dipropyl-8-[(1R,3r,5S,7s)-tricyclo[3.3.1.0³,⁷]nonan-3-yl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione

Smiles: CCCN1C(=O)C2NC(=NC=2N(CCC)C1=O)[C@]12C[C@@H]3C[C@H]1C[C@H](C2)C3

InChiKey: PJBFVWGQFLYWCB-OYEQCZOJSA-N

InChi: InChI=1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)/t12-,13+,14-,20-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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