Orexin 2 Receptor Agonist


Catalog No. Size PriceQuantity
M21280-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.IC50 value: 23 nM (EC50)Target: Orexin 2 ReceptorOrexin 2 Receptor Agonist shows not only potentactivity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.

Product information

CAS Number: 1796565-52-0

Molecular Weight: 586.70

Formula: C32H34N4O5S

Chemical Name: 4'-methoxy-N,N-dimethyl-3'-{[3-({2-[(3-methylphenyl)formamido]ethyl}amino)phenyl]sulfamoyl}-[1,1'-biphenyl]-3-carboxamide

Smiles: CC1C=CC=C(C=1)C(=O)NCCNC1=CC(=CC=C1)NS(=O)(=O)C1C=C(C=CC=1OC)C1=CC(=CC=C1)C(=O)N(C)C

InChiKey: RHLMXWCISNJNDH-UHFFFAOYSA-N

InChi: InChI=1S/C32H34N4O5S/c1-22-8-5-10-25(18-22)31(37)34-17-16-33-27-12-7-13-28(21-27)35-42(39,40)30-20-24(14-15-29(30)41-4)23-9-6-11-26(19-23)32(38)36(2)3/h5-15,18-21,33,35H,16-17H2,1-4H3,(H,34,37)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 32 mg/mL (54.54 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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