Quarfloxin


Catalog No. Size PriceQuantity
M21344-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template.

Product information

CAS Number: 865311-47-3

Molecular Weight: 604.67

Formula: C35H33FN6O3

Chemical Name: 15-fluoro-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-18-oxo-14-[3-(pyrazin-2-yl)pyrrolidin-1-yl]-12-oxa-1-azapentacyclo[11.7.1.0²,¹¹.0⁴,⁹.0¹⁷,²¹]henicosa-2,4,6,8,10,13(21),14,16,19-nonaene-19-carboxamide

Smiles: CN1CCC[C@H]1CCNC(=O)C1=CN2C3=C(OC4=CC5=CC=CC=C5C=C24)C(=C(F)C=C3C1=O)N1CC(CC1)C1C=NC=CN=1

InChiKey: WOQIDNWTQOYDLF-CGAIIQECSA-N

InChi: InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42-29-15-21-5-2-3-6-22(21)16-30(29)45-34-31(42)25(33(26)43)17-27(36)32(34)41-14-9-23(19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23?,24-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 1 mg/mL (1.65 mM; ultrasonic and adjust pH to 5 with 0.1 M HCL).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines. Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM.

Products are for research use only. Not for human use.

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