Sigma-1 receptor antagonist 3


Catalog No. Size PriceQuantity
M21370-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 has the potential for the neuropathic pain.

Product information

CAS Number: 1639220-17-9

Molecular Weight: 363.86

Formula: C19H23ClFN3O

Chemical Name: 5-chloro-2-(4-fluorophenyl)-4-methyl-6-[3-(piperidin-1-yl)propoxy]pyrimidine

Smiles: CC1=NC(=NC(OCCCN2CCCCC2)=C1Cl)C1C=CC(F)=CC=1

InChiKey: OAIHSWLLDNASTO-UHFFFAOYSA-N

InChi: InChI=1S/C19H23ClFN3O/c1-14-17(20)19(25-13-5-12-24-10-3-2-4-11-24)23-18(22-14)15-6-8-16(21)9-7-15/h6-9H,2-5,10-13H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 12.5 mg/mL (34.35 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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