ICA


Catalog No. Size PriceQuantity
M21597-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

Product information

CAS Number: 3374-88-7

Molecular Weight: 254.31

Formula: C13H10N4S

Chemical Name: N-[4-(pyridin-2-yl)-1,3-thiazol-2-yl]pyridin-2-amine

Smiles: C1SC(NC2C=CC=CN=2)=NC=1C1C=CC=CN=1

InChiKey: RYCUBTFYRLAMFA-UHFFFAOYSA-N

InChi: InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 49.5 mg/mL (194.64 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters.

Products are for research use only. Not for human use.

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