JNJ-5207852 dihydrochloride


Catalog No. Size PriceQuantity
M21750-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

JNJ-5207852 dihydrochloride is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.

Product information

CAS Number: 1782228-76-5

Molecular Weight: 389.40

Formula: C20H34Cl2N2O

Chemical Name: 1-(3-{4-[(piperidin-1-yl)methyl]phenoxy}propyl)piperidine dihydrochloride

Smiles: Cl.Cl.C(C1C=CC(=CC=1)OCCCN1CCCCC1)N1CCCCC1

InChiKey: RLLXSVVZCGBIJR-UHFFFAOYSA-N

InChi: InChI=1S/C20H32N2O.2ClH/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22;;/h8-11H,1-7,12-18H2;2*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels.

Products are for research use only. Not for human use.

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