Description
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.
Product information
CAS Number: 1037798-41-6
Molecular Weight: 536.09
Formula: C26H30ClN9S
Chemical Name: N3-(4-{4-[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]piperazin-1-yl}phenyl)-1-{2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl}-1H-1,2,4-triazole-3,5-diamine
Smiles: CC1=CSC2C(=NC(Cl)=NC=21)N1N=C(NC2C=CC(=CC=2)N2CCN(CC2)[C@@H]2C[C@@H]3C[C@H]2CC3)N=C1N
InChiKey: HLRDOMFIYHUBLJ-SQGPQFPESA-N
InChi: InChI=1S/C26H30ClN9S/c1-15-14-37-22-21(15)30-24(27)31-23(22)36-25(28)32-26(33-36)29-18-4-6-19(7-5-18)34-8-10-35(11-9-34)20-13-16-2-3-17(20)12-16/h4-7,14,16-17,20H,2-3,8-13H2,1H3,(H3,28,29,32,33)/t16-,17+,20+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
R916562 treatment at 85 mg/kg or 125 mg/kg orally b.i. d for 21 days results in statistically significant tumor growth inhibitions of 69% or 83% respectively. R916562 shows 73% reduction in fibroblast growth factor-induced neovascularization in a mouse corneal micropocket assay at a dose of 100 mg/kg and 50% reduction at 50 mg/kg.
Products are for research use only. Not for human use.
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