Catalog No. Size PriceQuantity
M21775-C Contact for quotation $100Unavailable


Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.

Product information

CAS Number: 70704-03-9

Molecular Weight: 296.36

Formula: C18H20N2O2

Chemical Name: methyl 6-ethyl-1,6-diazatetracyclo[⁵,¹⁶.0¹⁰,¹⁵]hexadeca-2,9(16),10(15),11,13-pentaene-2-carboxylate

Smiles: CCN1CCC2=C3C1CC=C(C(=O)OC)N3C1C=CC=CC2=1


InChi: InChI=1S/C18H20N2O2/c1-3-19-11-10-13-12-6-4-5-7-14(12)20-16(18(21)22-2)9-8-15(19)17(13)20/h4-7,9,15H,3,8,10-11H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [3H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [3H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [3H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [3H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats.

Products are for research use only. Not for human use.

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