AZD1979


Catalog No. Size PriceQuantity
M21780-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AZD1979 is a Melanin-concentrating hormone receptor 1 (MCHr1) antagonist with an IC50 of ~12 nM.

Product information

CAS Number: 1254035-84-1

Molecular Weight: 462.50

Formula: C25H26N4O5

Chemical Name: 6-{[4-({1-[5-(4-methoxyphenyl)-1,3,4-oxadiazole-2-carbonyl]azetidin-3-yl}oxy)phenyl]methyl}-2-oxa-6-azaspiro[3.3]heptane

Smiles: COC1C=CC(=CC=1)C1=NN=C(O1)C(=O)N1CC(C1)OC1C=CC(CN2CC3(C2)COC3)=CC=1

InChiKey: BKKPIQPFRAPEAY-UHFFFAOYSA-N

InChi: InChI=1S/C25H26N4O5/c1-31-19-8-4-18(5-9-19)22-26-27-23(34-22)24(30)29-11-21(12-29)33-20-6-2-17(3-7-20)10-28-13-25(14-28)15-32-16-25/h2-9,21H,10-16H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake, but an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs.

Products are for research use only. Not for human use.

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