Org-12962 hydrochloride


Catalog No. Size PriceQuantity
M21800-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model.

Product information

CAS Number: 210821-63-9

Molecular Weight: 302.12

Formula: C10H12Cl2F3N3

Chemical Name: 1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine hydrochloride

Smiles: Cl.FC(F)(F)C1C=CC(=NC=1Cl)N1CCNCC1

InChiKey: FVDILXYXZAAJOS-UHFFFAOYSA-N

InChi: InChI=1S/C10H11ClF3N3.ClH/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17;/h1-2,15H,3-6H2;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects.

Products are for research use only. Not for human use.

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