GR 113808

Catalog No. Size PriceQuantity
M21802-C Contact for quotation $100Unavailable


GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.

Product information

CAS Number: 144625-51-4

Molecular Weight: 393.50

Formula: C19H27N3O4S

Chemical Name: [1-(2-methanesulfonamidoethyl)piperidin-4-yl]methyl 1-methyl-1H-indole-3-carboxylate

Smiles: CN1C=C(C2=CC=CC=C12)C(=O)OCC1CCN(CCNS(C)(=O)=O)CC1


InChi: InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

GR113808 (intraperitoneal injection; 1 mg/kg; 5-7 days starting 24 h after induction of colitis) shows a significant increase in the disease activity index (DAI),which includes evaluation of weight loss, stool consistency, and presence of fecal blood.

Products are for research use only. Not for human use.

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