L-159282


Catalog No. Size PriceQuantity
M21841-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity.

Product information

CAS Number: 157263-00-8

Molecular Weight: 524.63

Formula: C30H28N4O3S

Chemical Name: N-{[4'-({2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl}methyl)-[1,1'-biphenyl]-2-yl]sulfonyl}benzamide

Smiles: CCC1=NC2C(=NC(C)=CC=2C)N1CC1C=CC(=CC=1)C1=CC=CC=C1S(=O)(=O)NC(=O)C1C=CC=CC=1

InChiKey: LIUNMFCWFYFUGQ-UHFFFAOYSA-N

InChi: InChI=1S/C30H28N4O3S/c1-4-27-32-28-20(2)18-21(3)31-29(28)34(27)19-22-14-16-23(17-15-22)25-12-8-9-13-26(25)38(36,37)33-30(35)24-10-6-5-7-11-24/h5-18H,4,19H2,1-3H3,(H,33,35)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

In the anesthetized chimpanzee, L-159282 (1 mg/kg, iv) produces 100% inhibition of the AII pressor response and is still active (52%) at 24 h. In aortic coarcted (high renin) rats, L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without reflex tachycardia. This dose of L-159282 reduces blood pressure to approximately the same level as both losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model.

Products are for research use only. Not for human use.

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